Advancements in medical interventions have allowed individuals with tetralogy of Fallot (ToF) to live longer, shifting the focus towards their quality of life. A recent study delves into the health-related quality of life (HRQoL) among adult ToF patients compared to their healthy counterparts.
Study Overview
Researchers recruited 115 participants, including 53 adults who had undergone surgical correction for ToF and 60 healthy controls. Utilizing the SF-36 and EQ-5D instruments, the study assessed various physical and mental health domains. Subgroup analyses further examined differences based on gender and age.
Key Findings
The results revealed that ToF patients reported significantly lower scores in physical functioning, role physical, general health, and the physical component summary of the SF-36 compared to healthy individuals. Interestingly, ToF patients exhibited a trend towards experiencing less bodily pain and higher vitality levels. Age emerged as a significant factor, with older ToF patients rating their physical health lower than younger patients and controls.
- Physical health deficits are more pronounced in older ToF patients.
- An unexpected increase in vitality was observed among ToF patients with optimal EQ-5D scores.
- Anxiety and depression were prevalent, affecting nearly half of the ToF group.
EQ-5D visual analogue scale (VAS) scores indicated that ToF patients perceived their overall health to be worse than that of the control group. Anxiety and depression emerged as the most frequently reported issues, affecting 45.3% of ToF patients. While controls generally reported better HRQoL across all domains, ToF patients with the highest health-related quality of life scores showed unexpected vitality advantages, though this was not sustained in those with lower scores.
The study underscores significant physical limitations faced by adult ToF survivors, while mental health impacts appear less pronounced compared to their healthy peers. These insights highlight the necessity for comprehensive HRQoL assessments tailored to individuals with congenital heart conditions.
Addressing the specific needs of ToF patients can lead to better-targeted interventions aimed at improving their daily functioning and overall well-being. Healthcare providers should prioritize regular HRQoL evaluations to identify and mitigate physical and mental health challenges faced by these individuals, ultimately enhancing their quality of life.

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