In a recent study conducted at the Condesa Specialized Clinics in Mexico, researchers have shed light on the effectiveness and economic viability of antiretroviral therapy (ART) for individuals living with HIV. The findings highlight significant insights into patient adherence and the overall cost of care, offering valuable guidance for public health strategies.
Adherence Rates and Challenges
The study assessed therapeutic adherence among 261 people living with HIV (PLwHIV) using the Adherence Follow-Up Questionnaire developed by The AIDS Clinical Trials Group (ACTG). Results revealed an average adherence index of 89.97. Despite this high adherence rate, 59% of participants reported periods of non-adherence. Notably, over 95% maintained an undetectable viral load, demonstrating ART’s effectiveness even when adherence is not optimal. The primary reasons for discontinuing ART included forgetting to take medication (49.37%), being away from home (45.57%), and disruptions to daily routines (25.95%).
Economic Impact of ART Programs
An economic Markov model was employed to evaluate the costs and health outcomes associated with ART over a five-year period from the perspective of the Condesa Specialized Clinics. The analysis revealed a cumulative cost of USD 8,432 per PLwHIV and an average of 3.80 quality-adjusted life years (QALYs), equating to USD 2,218 per QALY. These figures fall well below Mexico’s willingness-to-pay threshold of USD 13,790 per QALY, underscoring the cost-effectiveness of ART programs in managing HIV.
- High adherence rates correlate with effective viral suppression.
- Economic modeling supports the sustainability of ART programs.
- Challenges in adherence primarily stem from lifestyle factors.
The study’s economic model demonstrates that providing ART to PLwHIV is not only clinically effective but also financially sustainable within the Mexican healthcare framework. The cost per QALY remains significantly below the national threshold, suggesting that continued investment in ART programs is a prudent allocation of resources.
Extending ART coverage and addressing adherence barriers are crucial for maintaining the success of HIV management programs. Implementing strategies such as reminder systems, flexible medication schedules, and supportive services for individuals facing disruptions can further enhance adherence rates. Additionally, the economic findings reinforce the importance of sustaining ART programs, ensuring that they remain accessible and affordable for those in need.
The study provides a comprehensive evaluation of ART adherence and its economic implications, offering critical data to inform public health policies in Mexico. By balancing clinical outcomes with cost-effectiveness, healthcare providers can optimize HIV treatment strategies, ultimately improving the quality of life for individuals living with HIV.
Future initiatives should focus on personalized adherence support and exploring innovative solutions to minimize disruptions in ART regimens. Ensuring consistent access to ART will not only sustain viral suppression but also enhance the long-term sustainability of HIV care programs.
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