Tuesday, June 18, 2024

Comparative Effects of Azoximer Bromide and Surgery on Quality of Life in CRS Patients

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Chronic rhinosinusitis (CRS) without polyps significantly impacts patients’ quality of life, manifesting in various physical and emotional complaints. Recent studies have aimed to quantify the effects of different treatments on these patients, evaluating both medical and surgical interventions. One such study compared the outcomes of azoximer bromide treatment to functional endoscopic sinus surgery, focusing on changes in quality of life and emotional well-being.

Study Overview

The investigation utilized the Visual Analogue Scale (VAS) and the Sino-Nasal Outcome Test-22 (SNOT-22) questionnaires to assess patients’ conditions before treatment and three months thereafter. Patients were divided into two groups based on their treatment preferences: one group received functional endoscopic sinus surgery, while the other underwent a course of azoximer bromide (6 mg/ml, 1 ml daily for at least 10 days).

Results demonstrated that both treatment modalities improved quality of life. The median VAS score for patients receiving azoximer bromide decreased from 6.7 to 4.2, while those undergoing surgery saw a reduction from 6.4 to 4.8. Similarly, the SNOT-22 score for azoximer bromide patients decreased from 33 to 24, and for surgical patients, it reduced from 34 to 19.

Comparative Results

Surgical intervention showed a more substantial impact on certain domains of the SNOT-22, specifically “Rhinological symptoms,” “Extranasal symptoms,” and “Ear/facial symptoms.” However, both treatment options were equally effective in addressing “Psychological dysfunction” and “Sleep dysfunction” domains. These findings emphasize that while surgery might offer more pronounced improvements in specific physical symptoms, azoximer bromide is comparably effective in other quality of life areas.

Practical Inferences

Key Takeaways:

  • Azoximer bromide and surgery both significantly improve VAS and SNOT-22 scores in CRS patients.
  • Surgical treatment offers more pronounced improvements in physical symptom domains.
  • Azoximer bromide is equally effective in addressing psychological and sleep-related issues.
  • Patient choice of treatment can be guided by specific quality of life concerns and symptom domains.

In conclusion, both azoximer bromide and surgical treatment are effective in enhancing the quality of life for patients with chronic rhinosinusitis without polyps. While surgery shows greater efficacy in alleviating physical symptoms, azoximer bromide provides comparable benefits in psychological and sleep-related aspects, offering a viable alternative based on individual patient needs.

Original Article: Vestn Otorinolaringol. 2024;89(2):46-51. doi: 10.17116/otorino20248902146.

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