Tuesday, June 18, 2024

Enhancing Andrographolide Solubility and Absorption: A Review of Solid Dispersion Techniques

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Andrographolide (ADG) is a bioactive compound known for its therapeutic potential, yet its clinical application is hindered by poor water solubility and low bioavailability. Recent advancements in solid dispersion (SD) technologies offer promising solutions to these limitations. This systematic review delves into various SD methods and the polymers utilized to enhance ADG’s solubility and absorption, thereby paving the way for more effective pharmaceutical formulations.

Methodology and Approach

The study involved a comprehensive search of electronic databases such as PubMed, Web of Science, Scopus®, Embase, and ScienceDirect Elsevier® up to November 2023. Researchers meticulously reviewed relevant articles and extracted data through a standardized process, ensuring a qualitative synthesis of the findings. Two independent reviewers ensured the accuracy and reliability of the data extracted.

Key Findings

Solid dispersions significantly enhanced the solubility of ADG, achieving up to a 4.7-fold increase. This improved solubility was accompanied by a notable reduction in the 50% release time (T1/2) to less than five minutes. Additionally, SD formulations demonstrated enhanced absorption, as evidenced by higher peak plasma concentrations (Cmax), increased area under the curve (AUC), and reduced time to reach maximum concentration (Tmax).

Among the various SD techniques examined—rotary evaporation, spray drying, hot-melt extrusion, freeze drying, and vacuum drying—spray drying emerged as the most effective. This method facilitates a one-step process that eliminates the need for post-milling, thereby simplifying the production process.

Inferred Benefits and Applications

The following inferences can be drawn from the study, offering concrete insights for pharmaceutical development:

  • Soluplus-based SDs are particularly effective, offering significant enhancements in both solubility and absorption of ADG.
  • Spray drying stands out as a superior technique due to its efficiency and simplicity, making it ideal for large-scale production.
  • Enhanced solubility and absorption profiles can lead to more effective and faster-acting ADG formulations, potentially expanding its clinical applications.
  • Future research should focus on optimizing polymer selection and SD techniques to maximize the therapeutic potential of ADG.

These findings underscore the importance of SD techniques in improving the pharmacokinetic profile of ADG, offering valuable insights for the development of more effective ADG-based therapies.

Original Article: Pharmaceutics. 2024 May 20;16(5):688. doi: 10.3390/pharmaceutics16050688.

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