Saturday, June 22, 2024

Global Targets to Combat Antimicrobial Resistance Proposed for 2030

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Antimicrobial resistance (AMR) poses a severe threat to global health, transcending economic boundaries and challenging development goals such as child survival, healthy ageing, poverty reduction, and food security. The effectiveness of antimicrobials, considered a global public good, is at stake, necessitating urgent political will, defined targets, accountability frameworks, and financial investment.

High-Level Meeting at UN General Assembly

Scheduled for September 2024, the second high-level meeting on AMR at the UN General Assembly underscores the growing political interest in tackling this crisis. Notably, the 2016 UNGA resolution on AMR lacked concrete actions on targets, accountability, and funding. This upcoming meeting aims to address these gaps, propelling global efforts to curb AMR through ambitious yet achievable goals.

Proposed Global Targets for 2030

The article proposes the “10-20-30 by 2030” targets based on 2019 pre-pandemic levels: a 10% reduction in AMR-related mortality, a 20% decrease in inappropriate human antibiotic use, and a 30% reduction in inappropriate animal antibiotic use. These targets should be pursued within a framework ensuring universal access to effective antibiotics.

The WHO’s Access, Watch, Reserve (AWARE) classification system is recommended for defining, monitoring, and evaluating appropriate antibiotic usage. Countries with varying current antibiotic use levels must adjust their approaches accordingly. For instance, some should increase access to safe, narrow-spectrum antibiotics, while others need to curb inappropriate use of broader-spectrum and last-resort antibiotics.

Strategies for Progress

Enhanced infection prevention and control, improved access to clean water and sanitation, and increased vaccination coverage are critical strategies to counterbalance the effects of increased antibiotic usage, particularly in low-income settings. These measures are vital to prevent the selection of resistant strains.

Key Takeaways

  • Reduction in AMR-related mortality and inappropriate antibiotic use is crucial.
  • Universal access to effective, safe, and narrow-spectrum antibiotics must be prioritized.
  • Investment in sanitation, vaccination, and infection control can mitigate AMR risks.

Establishing the Independent Panel on Antimicrobial Access and Resistance is essential for global accountability and scientific guidance. Leaders from low- and middle-income countries must support these initiatives to ensure broad-based commitment and action.

The urgency of addressing AMR is clear, with decisive actions and international cooperation being imperative to achieve the proposed targets by 2030. The upcoming UNGA meeting represents a pivotal moment for advancing the global agenda against AMR.

Original Article: Lancet. 2024 May 20:S0140-6736(24)01019-5. doi: 10.1016/S0140-6736(24)01019-5. Online ahead of print.

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