Monday, July 15, 2024

Health-Related Quality of Life in PLWHA Co-Infected with SARS-CoV-2 in France: A Cross-Sectional Study

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The intersection of HIV/AIDS and COVID-19 presents unique challenges, particularly concerning the health-related quality of life (HRQL) of those affected. In France, a recent study delves into the HRQL among people living with HIV/AIDS (PLWHA) who are also co-infected with SARS-CoV-2. This investigation offers insights into various factors influencing different dimensions of HRQL, revealing critical information for targeted health interventions and policies.

Study Methodology and Measurements

The study employed a cross-sectional design, assessing HRQL using the PROQOL-HIV scale, which encompasses four key dimensions: Physical Health and Symptoms (PHS), Social Relationships (SR), Mental and Cognitive (MC), and Treatment Impact (TI). Linear regression models were utilized to identify factors associated with each dimension of HRQL.

Mean scores for these dimensions were recorded: 76.7 (± 21.1) for PHS, 79.2 (± 23.6) for SR, 67.3 (± 27.4) for MC, and 83.9 (± 16.5) for TI. Noteworthy variations in scores were observed, highlighting the multifaceted impacts of co-infection on HRQL.

Key Findings and Associations

The study identified several factors influencing HRQL scores among the participants. Employment status and COVID-19 knowledge were linked to higher PHS scores, while blood transfusion-acquired HIV and specific HIV stages were associated with lower PHS scores. In terms of SR, being in a couple correlated with higher scores, whereas factors like drug injection-acquired HIV and perceived COVID-19 vulnerability led to lower scores.

For the MC dimension, employment status and being born in France were associated with higher scores, while female sex and detectable HIV viral load contributed to lower scores. The TI dimension showed higher scores among those born in France and those with HIV acquired through homosexual/bisexual relationships, but lower scores were observed in those with detectable HIV viral load and psychiatric disorders.

Actionable Insights for Healthcare Providers

– Enhancing employment opportunities and providing COVID-19 education can improve physical health outcomes.
– Tailored support for individuals with blood transfusion-acquired HIV and those in advanced stages of HIV is crucial.
– Fostering strong social relationships can mitigate the negative impacts of co-infection on social well-being.
– Focused mental health interventions are needed, especially for women and those with a detectable viral load.
– Addressing psychiatric disorders is essential in improving the treatment impact dimension of HRQL.

In summation, the study underscores the diverse and significant impacts of co-infection on various HRQL dimensions among PLWHA. These insights are vital for developing targeted interventions aimed at enhancing the overall well-being of this vulnerable population.

Original Article: Qual Life Res. 2024 Jun 12. doi: 10.1007/s11136-024-03701-4. Online ahead of print.

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