Saturday, July 13, 2024

Impact of Pyrethroids on Sperm Quality: A Comprehensive Meta-analysis

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Pyrethroids, organic compounds derived from pyrethrum flowers, are extensively used in both household and commercial insecticides. Despite their efficacy in controlling insects and parasites, the associated toxicity, particularly concerning sperm health, poses a significant global challenge. Given the conflicting reports on pyrethroids’ impact on semen quality, an evaluation of their adverse effects is essential. This study meticulously reviews and analyzes the effects of pyrethroids on sperm quality through a systematic approach.

This research adhered to the PRISMA guidelines, employing a strategic search protocol across the internet with a combination of keywords. The eligibility criteria were determined using the PECO framework, and relevant data were meticulously gathered. The OHAT tool was utilized to assess the risk of bias, while evidence certainty was evaluated using the GRADE guidelines. A quantitative meta-analysis was conducted using Review Manager (RevMan).

Methodology

Out of 4,050 studies screened, only 12 met the inclusion criteria. These studies originated from China (4), Japan (3), Poland (3), and the United States (2), encompassing a total of 2,050 male subjects. All selected studies were cross-sectional in nature. The meta-analysis revealed that pyrethroid exposure notably reduced sperm motility.

Regional Insights

Subgroup analyses based on regions indicated that pyrethroids significantly decreased sperm motility in men from Poland and the United States, while sperm count was notably reduced in men from Japan. Additionally, pyrethroid exposure led to a decrease in sperm concentration among Polish men but surprisingly increased sperm concentration among men in the United States.

Concrete Inferences

– Pyrethroid exposure is linked to reduced sperm motility, particularly in Poland and the United States.
– Men in Japan exposed to pyrethroids experience a significant decrease in sperm count.
– Sperm concentration decreases among Polish men but increases among American men when exposed to pyrethroids.

The study, despite revealing inconsistent evidence on the overall detrimental effects of pyrethroids on semen quality, provides substantial findings that highlight the harmful potential of pyrethroids on sperm motility, count, and concentration. Future research should focus on assessing semen quality in men exposed to varying levels of pyrethroids, utilizing prospective cohort studies or controlled cross-sectional designs.

Original Article: Front Toxicol. 2024 May 30;6:1395010. doi: 10.3389/ftox.2024.1395010. eCollection 2024.

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