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Improve Health-Related Quality of Life Assessments Health Technology Assessment in France

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The health-related quality of life (HRQoL) of patients is an integral part of the evaluation of treatments by health technology assessment (HTA) bodies and payers. To identify how HRQoL evaluations can be better integrated into the French HTA, a comparative study of three health systems was conducted. The goal is to bring forward recommendations that could pave the way for further innovations for French patients.

In the study, the methodologies of the French, German, and British HTA were reviewed. A systematic review was also conducted of all French and German HTA appraisals from the period of 1st January 2019 to 31st December 2021. Additionally, an advisory board of 11 ex-HTA leaders, payers, methodologists, healthcare providers, and patient advocates from France, Britain, and Germany was set up. The board’s role was to discuss ways to improve the acceptance and adoption of health-related quality of life evidence in France.

Health-Related Quality of Life

Critiquing the Acceptance of Health-Related Quality of Life Evidence in HTA Appraisals

The systematic review of HTA appraisals revealed a higher HRQoL data rejection rate in France. In more than 75% of cases, the HRQoL evidence submitted was not accepted for assessment. This was usually due to methodological reasons such as the data being considered exploratory. Between 16-75% of the appraisals mentioned HRQoL evidence, with the frequency varying by therapeutic area. The French HTA was found to be more restrictive in its approach than the IQWiG.

Based on these findings, collaborative proposals have been put forward for the industry and the HAS to improve the acceptance of HRQoL evidence. The goal is to create a positive feedback loop between HAS and the industry along four dimensions: patient perception, testing hierarchy, trial design, and data collection.


Original Article DOI: 10.1186/s12961-023-01081-8

Original title: Opportunities to improve the adoption of health-related quality of life evidence as part of the French Health Technology Assessment process

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