Saturday, June 15, 2024

Innovative Vaccine Development: SpyBiotech and University of Oxford Collaborate on Epstein-Barr Virus Research

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SpyBiotech, a biotechnology company known for its innovative vaccine platform technologies targeting infectious diseases, cancer, and chronic diseases, has announced a significant research collaboration with the University of Oxford. This collaboration aims to develop a groundbreaking innovative vaccine against the Epstein-Barr virus (EBV), a commonly spread virus linked to several serious health conditions, including infectious mononucleosis, various cancers, and multiple sclerosis.

Under the terms of the sponsored research agreement, SpyBiotech will provide Oxford researchers with access to their proprietary SPYVLP vaccine platform. This technology utilizes a unique protein “superglue” mechanism that securely binds antigens to vaccine delivery platforms, enhancing immunogenicity and efficacy while minimizing delivery risks. Oxford’s team, led by Professor Sandy Douglas at the Jenner Institute, will work to advance three vaccine candidates targeting EBV into a Phase I clinical trial.

“This research collaboration is a crucial step forward in addressing a widespread virus with no existing vaccines or therapeutics,” said Mark Leuchtenberger, Chief Executive Officer of SpyBiotech. “Studies have shown that EBV triggers a range of severe health conditions, including certain cancers and multiple sclerosis. A recent study by Stanford Medicine, led by senior author Dr. William Robinson, found that 99% of MS patients have EBV antibodies in their blood, indicating prior infection. There is a significant need for an EBV vaccine.”

Innovative Vaccine for Epstein-Barr Virus: SpyBiotech and Oxford Collaborate to Address Severe Health Risks

Epstein-Barr virus is one of the most commonly spread human viruses, transmitted primarily through saliva. While most individuals recover from EBV infections within a few weeks, the virus can lead to severe conditions such as mononucleosis, meningitis, encephalitis, and certain cancers. Recent research also suggests a strong association between EBV infections and the development of multiple sclerosis and some lymphomas. The collaboration aims to address this critical gap by developing a innovative vaccine that can prevent the spread of EBV and reduce the incidence of these associated diseases. The research project will combine Oxford’s groundbreaking academic research capabilities with SpyBiotech’s proprietary SPYVLP platform technology to develop and test these innovative vaccine candidates.

The approval of UCERIS rectal aerosol foam, another product in the gastrointestinal franchise, was based on two pivotal clinical studies that demonstrated significant effectiveness in inducing remission. Similarly, the new EBV vaccine candidates will undergo rigorous testing. In the initial Phase I clinical trials, the safety, tolerability, and immunogenicity of the vaccine candidates will be assessed. These trials are designed to establish the foundation for subsequent phases that will further evaluate the efficacy and long-term benefits of the vaccine.

Dr. Sumi Biswas, President and Chief Scientific Officer of SpyBiotech, expressed enthusiasm for the collaboration, stating, “We are eager to progress these vaccine candidates that target multiple EBV antigens to Phase I clinical trials with Professor Sandy Douglas and his team at the Jenner Institute, University of Oxford, following the promising pre-clinical data generated.” SpyBiotech is already conducting a Phase I trial assessing the safety and immunogenicity of its HCMV vaccine, which features a six-month dosing schedule and is being carried out in the UK. This ongoing research reflects SpyBiotech’s commitment to advancing innovative therapies that address unmet medical needs.

Innovative Vaccine

SpyBiotech and Oxford’s Collaboration Promises Major Public Health Advancements

The development of a vaccine against EBV holds significant potential not only for preventing the immediate symptoms and complications associated with the virus but also for reducing the long-term risk of serious conditions like multiple sclerosis and various cancers. The successful development and deployment of this vaccine could mark a substantial advancement in public health, protecting against a virus that affects millions globally.

SpyBiotech is at the forefront of developing novel vaccines using their SPYVLP platform, which leverages their proprietary protein “superglue” technology. This approach has shown promise in enhancing the efficacy and safety of vaccines across various infectious and chronic diseases. The University of Oxford, renowned for its pioneering research and contributions to medical science, brings extensive expertise and resources to this collaboration. The Jenner Institute, in particular, has a strong track record in vaccine development, making it an ideal partner for this ambitious project.

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The collaboration between SpyBiotech and the University of Oxford represents a significant step forward in the fight against the Epstein-Barr virus. By combining cutting-edge technology with world-class research capabilities, this partnership aims to develop a much-needed vaccine that could prevent a range of serious health conditions linked to EBV. As the project progresses into clinical trials, it holds the promise of delivering a transformative impact on public health, providing hope for millions of individuals at risk of EBV-related diseases.


Resource: SpyBiotech, May 23, 2024

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