A recent cross-sectional study conducted in Belgium and the Netherlands has shed light on the effects of keratinocyte carcinoma (KC) on patients’ health-related quality of life (HRQoL). With KC accounting for the majority of skin cancer cases, understanding its impact is crucial for patient care and support.
Study Design and Methodology
The research encompassed 715 participants, divided into two groups: 332 individuals with a single KC and 383 with multiple KCs. Utilizing both disease-specific and generic HRQoL instruments, the study employed the Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) questionnaire alongside the EuroQol 5-Dimension 5-level (EQ-5D-5 L), visual analog scale (VAS), 15-dimensions (15D), and the time trade-off (TTO) technique to assess quality of life metrics.
Key Findings and Implications
Results indicated that the overall impact of KC on HRQoL ranges from low to moderate. Specifically, BaSQoL subscores for appearance and interactions with others reflected minimal effects. However, patients suffering from multiple KCs experienced significantly higher levels of worry and reported poorer perceived health compared to those with a single KC. Interestingly, measures such as VAS, 15D, and TTO did not show substantial differences between the two groups.
- Multiple KC cases are linked to increased anxiety and concerns about health.
- Single KC cases maintain a relatively stable quality of life across various metrics.
- Generic HRQoL instruments may not fully capture the nuanced impacts of KC.
- Support systems for multiple KC patients could enhance their quality of life.
The findings highlight the importance of tailored support for individuals with multiple KCs, as they face unique challenges that single KC patients do not. Healthcare providers should consider integrating specific interventions aimed at alleviating the heightened worries and perceived health declines observed in these patients.
Understanding the differential impacts of single versus multiple KCs can inform better clinical practices and resource allocation. By recognizing that while KC generally has a modest effect on quality of life, the complexities increase with multiple occurrences, strategies can be developed to provide comprehensive care that addresses both the physical and psychological needs of patients.
Effective management of KC should not only focus on the clinical treatment of the carcinoma itself but also on the holistic well-being of the patient. This approach ensures that improvements in clinical outcomes are paralleled by enhancements in patients’ overall life satisfaction and mental health.

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