New research reveals that Medicaid programs enforcing sobriety requirements before approving direct-acting antivirals (DAAs) for hepatitis C patients significantly increase healthcare utilization and costs. The study highlights the financial and medical burdens imposed by these restrictions on both patients and the healthcare system.
Study Overview
Researchers conducted a retrospective analysis using the Anlitiks All Payor Claims data from January 2020 to June 2022. The study focused on Medicaid-insured adults aged 18-64 with hepatitis C who began DAA treatment between January and December 2021. Participants were divided into two groups based on their state’s sobriety restriction: those in states with sobriety requirements (SR) and those without (NSR).
Key Findings
The analysis included 2,295 patients under sobriety restrictions and 4,623 without. Those in SR states were older on average, had fewer males, and lower rates of substance use compared to the NSR group. Patients facing sobriety restrictions showed higher rates of hospitalizations, emergency visits, outpatient services, and professional office visits. Additionally, the SR cohort incurred significantly higher medical and pharmacy costs across all categories.
– Sobriety restrictions correlate with increased inpatient and outpatient visits by 2x and 1.5x respectively.
– Medical costs for SR patients tripled compared to their NSR counterparts.
– States enforcing sobriety requirements may face challenges in meeting WHO’s 2030 hepatitis C elimination goals.
– Delays in DAA initiation due to sobriety rules contribute to higher overall healthcare expenditures.
Patients required to meet sobriety conditions before accessing hepatitis C treatments not only experience delays in receiving essential medication but also place a greater strain on healthcare resources. The elevated costs and increased healthcare service utilization observed in SR states underscore the financial inefficiencies of such restrictions.
Healthcare policymakers must reconsider sobriety prerequisites to optimize both patient outcomes and economic efficiency. Streamlining access to DAAs without mandatory sobriety periods could reduce unnecessary healthcare spending and accelerate progress toward global hepatitis C eradication targets.
By eliminating sobriety restrictions, Medicaid programs can enhance the timely treatment of hepatitis C, leading to better health outcomes and lower overall costs. This adjustment would not only benefit individual patients but also contribute to a more sustainable healthcare system.

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