Tuesday, June 18, 2024

New Methods for Estimating Hydroxyzine HCl Show Promise

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Recent advancements in analytical chemistry have introduced two novel methodologies for estimating hydroxyzine HCl, showcasing significant improvements over previous techniques. These methods, based on resonance Rayleigh scattering (RRS) and spectrofluorimetric analysis, utilize 2,4,5,7-tetraiodofluorescein (erythrosin B) in an acidic medium to form an association complex with hydroxyzine HCl. These techniques not only provide precise and accurate measurements but also emphasize sustainability and economic feasibility, marking a substantial step forward in pharmaceutical analysis.

Methodological Innovations

The spectrofluorimetric technique relies on the quenching of fluorescence intensity of erythrosin B by hydroxyzine at 551.5 nm, with an excitation wavelength of 527.5 nm. This method demonstrates a linear response within the range of 0.15-1.5 μg ml-1. In contrast, the RRS method amplifies the RRS spectrum at 348 nm upon interaction with hydroxyzine HCl, showing linearity within the range of 0.1-1.2 μg ml-1. Both methods exhibit exceptional sensitivity, with limits of detection (LOD) reported at 0.047 μg ml-1 for the spectrofluorimetric method and 0.033 μg ml-1 for the RRS method.

Practical Applications

The developed procedures were successfully employed to estimate the content of hydroxyzine HCl in pharmaceutical tablets, yielding satisfactory recovery rates. These findings underscore the practical applicability of the methodologies in real-world pharmaceutical contexts. Moreover, the integration of four greenness and whiteness algorithms in evaluating these methods highlights their superiority in terms of sustainability, cost-effectiveness, and analytical performance compared to previously reported methods.

Key Inferences

  • The new methods provide highly sensitive and accurate measurements of hydroxyzine HCl.
  • Sustainable and economical, these techniques are superior to older methods.
  • Both methods show linear results within specific concentration ranges, enhancing their reliability.
  • Successful application in pharmaceutical tablets indicates strong practical value.

In conclusion, the innovative use of resonance Rayleigh scattering and spectrofluorimetric techniques for estimating hydroxyzine HCl not only offers enhanced analytical performance but also aligns with the growing emphasis on sustainability and cost-effectiveness in pharmaceutical analysis. These advancements pave the way for more reliable and eco-friendly analytical practices in the field.

Original Article: Luminescence. 2024 May;39(5):e4766. doi: 10.1002/bio.4766.

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