Monday, July 15, 2024

Prevalence and Factors Influencing Canine Enteric Coronavirus in Mainland China

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Canine enteric coronavirus (CECoV) remains a significant concern for dog owners and veterinary professionals in mainland China, reflecting broader implications for animal health management. A systematic review and meta-analysis were conducted to evaluate the prevalence of CECoV and identify factors that contribute to its spread. This research provides crucial insights into the virus’s epidemiology, offering guidance for more effective control and prevention strategies.

Comprehensive Study Methodology

A thorough literature search was carried out across several databases, including PubMed, CNKI, Wanfang, and CQVIP, to gather relevant studies on CECoV epidemiology in China. The selection of eligible studies was guided by predefined criteria, and the extracted data were synthesized and assessed for quality using the JBI assessment tool. Heterogeneity among studies was evaluated with the I2 test, and further analyses were conducted to explore variations in CECoV prevalence by different factors.

Key Findings and Prevalence Rates

From a total of 27 studies involving 21,034 samples, the pooled prevalence of CECoV in mainland China was found to be 0.30 (95% CI 0.24-0.37). This finding underscores the persistent circulation of the virus across the region. Subgroup analyses highlighted higher prevalence rates in younger dogs, multi-dog households, and certain areas such as southwest China. Seasonal variations were also noted, with lower prevalence rates during the summer months. Interestingly, no significant differences in prevalence were observed by gender.

These findings suggest that certain demographic and environmental factors significantly influence CECoV prevalence, which has implications for market access and resource allocation in veterinary health services. Understanding these factors can help in designing targeted interventions to control the virus more effectively.

Market Access Insights

– The persistence of CECoV highlights the need for continuous monitoring and surveillance, particularly in high-prevalence regions.
– Effective control measures could include targeted vaccination programs focusing on younger dogs and multi-dog households.
– Seasonal variations in prevalence should inform the timing of preventive measures, with heightened efforts during higher-risk periods.
– Regional differences in prevalence suggest that localized strategies may be more effective than a one-size-fits-all approach.

In conclusion, this systematic review and meta-analysis provide a comprehensive overview of CECoV prevalence in mainland China, identifying key factors associated with its spread. These insights are invaluable for informing ongoing and future efforts to control the virus, ensuring better health outcomes for dogs and potentially mitigating risks to human health.

Original Article:

Virol J. 2024 Jul 9;21(1):155. doi: 10.1186/s12985-024-02425-8.

ABSTRACT

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BACKGROUND: Canine enteric coronavirus (CECoV) is a prevalent infectious disease among dogs worldwide, yet its epidemiology in mainland China remains poorly understood. This systematic review and meta-analysis aimed to assess the prevalence of CECoV in mainland China and identify factors influencing its prevalence.

METHODS: A comprehensive literature search was conducted across multiple databases for studies regarding CECoV epidemiology of China. PubMed, CNKI, Wanfang, and CQVIP were searched to obtain the studies. Eligible studies were selected based on predefined criteria, and data were extracted and synthesized. The quality the studies was assessed using the JBI assessment tool. Heterogeneity was checked using I2 test statistics followed by subgroup and sensitivity analysis. Subgroup analyses were performed to explore variations in CECoV prevalence by factors such as year, region, season, health status, social housing type, gender, age, and breed. Publication bias was assessed using a funnel plot and eggers test that was followed by trim and fill analysis.

RESULTS: A total of 27 studies involving 21,034 samples were included in the meta-analysis. The overall pooled prevalence of CECoV in mainland China was estimated to be 0.30 (95% CI 0.24-0.37), indicating persistent circulation of the virus. Subgroup analyses revealed higher prevalence rates in younger dogs, multi-dog households, apparently healthy dogs, and certain regions such as southwest China. Seasonal variations were observed, with lower prevalence rates in summer. However, no significant differences in prevalence were found by gender.

CONCLUSIONS: This study provides valuable insights into the epidemiology of CECoV in mainland China, highlighting the persistent circulation of the virus and identifying factors associated with higher prevalence rates. Continuous monitoring and surveillance efforts, along with research into accurate detection methods and preventive measures, are essential for the effective control of CECoV and mitigation of its potential impact on animal and human health.

PMID:38982509 | DOI:10.1186/s12985-024-02425-8

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