Saturday, July 13, 2024

The Impact of NAD+ Precursors on Glucose Metabolism and Liver Enzymes: A Comprehensive Study

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In the quest to understand the multifaceted impacts of NAD+ precursor supplements, researchers have delved into a systematic review and meta-analysis. This study aimed to synthesize the effects of these supplements on glucose metabolism, C-reactive protein (CRP), and liver enzymes. The findings provide a nuanced view that could significantly inform both clinical practices and future research directions.

Study Design and Methodology

The comprehensive review involved an extensive search across PubMed/MEDLINE, Web of Science, SCOPUS, and Embase databases. Controlled trials focusing on the impacts of NAD+ precursors on glucose metabolism, CRP, and liver enzymes were meticulously selected. The final analysis encompassed data from 45 studies, including 9256 participants. Using a random-effects model, the researchers calculated pooled weighted mean differences (WMD) and 95% confidence intervals (CI) to estimate the outcomes accurately.

Key Findings

The meta-analysis revealed that NAD+ precursor supplementation significantly increased glucose levels (WMD: 2.17 mg/dL, 95% CI: 0.68, 3.66, P = 0.004) and HbA1c (WMD: 0.11, 95% CI: 0.06, 0.16, P

Subgroup Analysis Insights

Subgroup analysis highlighted that interventions extending beyond 12 weeks resulted in more substantial increases in glucose levels. Furthermore, it was noted that nicotinic acid (NA) supplementation led to greater rises in glucose and HbA1c levels compared to nicotinamide (NE) supplementation. These insights underscore the importance of considering the duration and type of NAD+ precursor used in supplementation protocols.

Practical Takeaways

• Extended supplementation (over 12 weeks) may lead to increased glucose levels.
• Nicotinic acid has a more pronounced effect on glucose and HbA1c than nicotinamide.
• The reduction in CRP suggests potential anti-inflammatory benefits.
• No significant impact on liver enzymes, indicating safety in hepatic functions.

In conclusion, NAD+ precursor supplementation appears to enhance glucose metabolism while reducing inflammation as indicated by CRP levels. However, it does not significantly affect liver enzyme markers, suggesting its safety concerning hepatic functions. These findings may guide clinical decisions and future research on the therapeutic use of NAD+ precursors.

Original Article: Nutr Metab (Lond). 2024 Jun 24;21(1):35. doi: 10.1186/s12986-024-00812-0.

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