Tuesday, April 16, 2024

UK’s NICE Endorses Brukinsa as Treatment for Chronic Lymphocytic Leukemia

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NICE has issued the final draft guidance (FDG) endorsing Brukinsa as an advised treatment for suitable adults with untreated Chronic Lymphocytic Leukemia (CLL) if there is a 17p deletion or TP53 mutation. Furthermore, it is also proposed for adults with untreated CLL without a 17p deletion or TP53 mutation, and fludarabine-cyclophosphamide-rituximab (FCR) or bendamustine plus rituximab (BR) is unsuitable, as well as relapsed or refractory CLL.

Dr. Robert Mulrooney, BeiGene UK and Ireland general manager, has reportedly stated that this approval follows the earlier sanction of Brukinsa by NICE in July 2022 as the sole cost-effective treatment for patients with Waldenstrom’s macroglobulinemia. BeiGene, despite being a relatively new player in the UK market, is swiftly making a name for itself as a company that can provide innovative cancer medicines that are both accessible and affordable for UK patients.

Brukinsa, discovered by BeiGene scientists, is a small molecule inhibitor of Bruton’s tyrosine kinase (BTK). It is presently undergoing worldwide clinical evaluation as a monotherapy and in combination with other therapies for a variety of B-cell malignancies.

This therapy was designed to ensure continuous and effective inhibition of the BTK protein by optimizing factors such as bioavailability, half-life, and selectivity, as new BTK is consistently synthesized. Brukinsa features differentiated pharmacokinetics compared to other approved BTK inhibitors.

The therapy has demonstrated its effectiveness in inhibiting the growth of malignant B cells in various disease-relevant tissues.

Brukinsa’s approval by the NICE is a significant step forward for patients with CLL, especially for those with the 17p deletion or TP53 mutation. The continued clinical evaluation of the drug worldwide also holds promise for its potential use in treating other B-cell malignancies. BeiGene’s commitment to making innovative cancer treatments accessible and affordable is noteworthy and provides hope for patients across the UK.

In essence, the endorsement of Brukinsa by NICE marks a significant progression in the treatment of Chronic Lymphocytic Leukemia in the UK. This not only provides a beneficial treatment option for patients but also emphasizes the role of innovative and cost-effective therapies in improving patient outcomes in the field of oncology.

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