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What is IQWIG?

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What is IQWIG?

Today, I would like to discuss The Institute for Quality and Efficiency in Health Care (IQWiG) which stands as a pivotal institution in the German healthcare landscape. Established to enhance the quality and efficiency of healthcare provided to patients, IQWiG plays a crucial role in assessing the benefits and drawbacks of medical interventions.

This encompasses a wide range of healthcare aspects, from medications and procedures to the evaluation of diagnostic and therapeutic methodologies based on rigorous scientific evidence.


IQWiG was founded in 2004, following the enactment of health reform laws in Germany that sought to improve the standard and efficiency of healthcare services. The institute was conceived as an independent entity to provide objective and scientifically grounded information to the Federal Joint Committee (G-BA) in Germany, the body responsible for determining which medical services are covered by the public health insurance system. Over the years, IQWiG has established itself as a key player in the healthcare sector, contributing to policy decisions that affect the health and well-being of millions.

Objectives and Functions

The Institute for Quality and Efficiency in Health Care (IQWiG) is tasked with a multifaceted mission aimed at ensuring the highest standards of healthcare. The core objectives and functions of IQWiG can be summarized as follows:

Primary Goals

  1. Evidence-Based Assessments: IQWiG conducts thorough evaluations of medical interventions, including drugs, medical devices, and treatment methods. The primary goal is to assess the benefits and harms based on available scientific evidence, ensuring that patients receive effective and safe healthcare services.
  2. Healthcare Decision Support: The institute provides critical support to healthcare decision-makers, notably the Federal Joint Committee (G-BA) and the Ministry of Health. By supplying evidence-based recommendations, IQWiG aids in the determination of which medical services should be covered by the statutory health insurance system.
  3. Transparency and Information Dissemination: A significant function of IQWiG is to promote transparency in healthcare decisions and to disseminate reliable health information to patients and healthcare professionals. This is achieved through the publication of research findings, health information, and treatment guidelines on its website.

Range of Activities

  • Health Technology Assessment (HTA): Conducting HTAs to evaluate the effectiveness, cost-effectiveness, and social implications of healthcare interventions.
  • Guideline Development: Collaborating in the development of clinical practice guidelines to standardize patient care based on the best available evidence.
  • Patient Information: Providing accessible and understandable health information to the public, empowering patients to make informed healthcare decisions.
  • International Collaboration: Engaging in international networks and partnerships to share knowledge, methodologies, and best practices in health care assessment and policy-making.

Methodology: The HTA Approach of IQWiG

IQWiG’s approach to evaluating medical interventions is characterized by a rigorous and transparent methodology. This involves a systematic review of existing studies and data to assess the relative benefits and harms of healthcare interventions. The methodology is grounded in the principles of evidence-based medicine and adheres to internationally recognized standards for health technology assessment.

By employing a comprehensive and methodical approach, IQWiG ensures that its assessments and recommendations are based on the best available evidence, thereby contributing to the efficient allocation of healthcare resources and the improvement of patient care in Germany.

HTA Process in IQWiG

The Health Technology Assessment (HTA) process at IQWiG embodies a comprehensive and systematic evaluation of the properties, effects, and impacts of health technologies. This multidisciplinary process is designed to inform healthcare decision-making by compiling, summarizing, and critically appraising all relevant information about the medical, social, economic, and ethical issues related to the use of health technology. Here’s a more detailed look at IQWiG’s HTA approach:

1. Scoping

  • Objective Definition: The process begins with a clear definition of the research question, outlining the scope of the assessment. This includes specifying the technology to be assessed, the target population, the relevant outcomes, and the comparison interventions.
  • Stakeholder Involvement: Early engagement with stakeholders, including healthcare professionals, patients, and manufacturers, helps to ensure that the assessment addresses relevant and significant questions.

2. Systematic Review

  • Literature Search: A systematic search of the scientific literature is conducted to identify all relevant studies that meet predefined inclusion criteria. This search is comprehensive, covering multiple databases to ensure no significant evidence is overlooked.
  • Data Extraction and Synthesis: Data from the included studies are extracted and synthesized. This may involve quantitative methods, such as meta-analysis, or qualitative synthesis, depending on the nature of the evidence.

3. Critical Appraisal

  • Assessment of Study Quality: Each study is critically appraised to assess its methodological quality and risk of bias. This step is crucial for understanding the reliability and applicability of the evidence.
  • Evidence Grading: The overall body of evidence for each outcome is graded according to its strength and reliability, which helps in making recommendations.

4. Economic Evaluation

  • Cost-Effectiveness Analysis: Where applicable, an economic evaluation is performed to compare the costs and outcomes (often in terms of quality-adjusted life years, QALYs) of different health technologies. This aids in assessing the value for money of interventions.
  • Budget Impact Analysis: The potential financial impact on the healthcare system is also considered, helping policymakers understand the affordability of new technologies.

5. Patient and Public Involvement

  • Incorporating Patient Perspectives: Patient preferences, experiences, and outcomes are integral to the HTA process. IQWiG places a strong emphasis on including patient-reported outcomes and engaging with patient groups to ensure the assessments reflect patients’ values and needs.

6. Reporting and Dissemination

  • Transparent Reporting: The findings of the HTA are reported transparently, detailing the methods, results, and conclusions. This ensures that the basis for recommendations is clear and comprehensible.
  • Dissemination: The results are disseminated to all relevant stakeholders, including healthcare decision-makers, practitioners, and the public, to inform healthcare policy and practice.

IQWiG’s HTA methodology is a cornerstone of its mission to improve healthcare quality and efficiency. By employing a rigorous, evidence-based approach, IQWiG ensures that healthcare decisions in Germany are informed by the best available scientific evidence, ultimately aiming to deliver optimal health outcomes for patients.

Impact ıf IQWiG

IQWiG’s work has had a substantial impact on healthcare in Germany and beyond. By providing evidence-based assessments and recommendations, the institute has contributed to significant improvements in the quality and efficiency of healthcare services. Some notable impacts include:

  • Informed Decision-Making: IQWiG’s assessments have been instrumental in guiding the decisions of the Federal Joint Committee (G-BA) regarding which treatments and technologies should be covered by statutory health insurance. This ensures that only effective, safe, and cost-efficient interventions are made available to patients.
  • Enhanced Patient Safety: By rigorously evaluating the risks and benefits of medical interventions, IQWiG has helped to identify and mitigate potential harms, thereby enhancing patient safety.
  • Promotion of Evidence-Based Practice: IQWiG’s work has encouraged the adoption of evidence-based practices among healthcare professionals, contributing to more effective and patient-centered care.

Challenges and Criticism

Despite its achievements, IQWiG has faced challenges and criticism, including:

  • Controversial Decisions: Some of IQWiG’s recommendations, particularly those involving the non-recommendation of popular but insufficiently proven treatments, have sparked controversy among patients, healthcare providers, and pharmaceutical companies.
  • Methodological Critiques: Critics have sometimes questioned the methodology used by IQWiG, arguing that it may be overly stringent or not fully transparent.
  • Stakeholder Engagement: There have been calls for greater involvement of stakeholders, including patients and industry representatives, in the HTA process to ensure a more balanced and inclusive approach.

Possible Future Directions

Looking ahead, IQWiG is poised to continue evolving in response to the changing healthcare landscape.

Future directions include:

  • Adapting to New Technologies: As medical technology advances, IQWiG is focusing on developing methodologies to assess innovative treatments, including personalized medicine and digital health interventions.
  • Increasing Transparency and Participation: Efforts are underway to enhance the transparency of the HTA process and to involve a broader range of stakeholders, including more active patient participation.
  • International Collaboration: IQWiG is expanding its involvement in international networks to share knowledge and harmonize HTA methodologies, thereby contributing to global healthcare improvement.


IQWiG plays a critical role in shaping healthcare policies and practices in Germany, with its work having far-reaching implications for patient care, healthcare efficiency, and the overall quality of the health system. Despite facing challenges and criticism, the institute remains committed to its mission of promoting evidence-based healthcare and is continuously adapting to meet the needs of an evolving healthcare environment.

Güvenç Koçkaya, March 2024




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